Description
| PROPERTY | VALUE |
| Common names | JWH-073, Spice |
| Systematic name | naphthalen-1-yl-(1-butylindol-3-yl)methanone |
jwh-073 is an analgesic chemical from the naphthoylindole family that acts as a partial agonist at both the cb1 and cb2 cannabinoid receptors. it is somewhat selective for the cb1 subtype, with affinity at this subtype approximately 5x the affinity at cb2. the abbreviation jwh stands for john w. huffman, one of the inventors of the compound.
jwh-073 gained popularity in april 2009, when it was claimed by chemists at the university of freiburg to have been found in a “fertilizer” product called “forest humus”, along with another synthetic cannabinoid, cp 47,497. it was subsequently found as a chemical within the popular synthetic cannabis blend spice, which had been sold in numerous countries around the world since 2002.
cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. jwh-073 is orally active when dissolved in a lipid, which can increase the duration significantly. like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.
chemistry
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