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Carfentanil has been sold since 1986 under the brand name “Wildnil” for use in tranquilizer darts in combination with an α2-adrenoreceptor agonist for large mammals including elk and elephants.
It is chosen for its high therapeutic index as the fatal dose of carfentanil is approximately the same as that of fentanyl despite the much higher opioid activity.
Radiolabelled carfentanil is widely used as a selective radiotracer in animal and human positron emission tomography (PET) imaging studies of the μ-opioid system due to its high affinity for receptors.
Carfentanil or carfentanyl is a structural analog of the synthetic opioid analgesic fentanyl. Short-acting and with fast onset, it has weight for weight, around a hundred times stronger effects than fentanyl and thousands of times stronger than heroin. It is more effective at reducing pain response in rats than any other opioid
